CV - Lorraine Jadeski

Lorraine Jadeski, Ph.D.

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Education and Academic Distinctions Doctor of Philosophy (Ph.D.), Anatomy and Cell Biology (2003) University of Western Ontario London, Ontario CANADA Dissertation: The Role of Nitric Oxide on Tumour Progression Areas of Specialization: In Vivo and In Vitro Tumour Biology (tumour angiogenesis, migration, proliferation and invasion); Intracellular Signaling Awarded Ontario Graduate Scholarship by the Province of Ontario for three consecutive years (1998-2001) Awarded Special University Scholarship by the University of Western Ontario (1997-1998)
Master of Science (M.Sc.), Health Studies and Gerontology (1996) University of Waterloo Waterloo, Ontario CANADA Dissertation: The Role of Exercise on Innate Immunity using Tumours of Varying Metastatic Capacity Awarded Graduate Student Scholarships by the University of Waterloo (1994: Awarded 2 scholarships; 1995: Awarded 1 scholarship) Awarded Graduate Student Association Scholarship by the University of Waterloo (1994) Bachelor of Science (B.Sc. Honours), Human Kinetics (1990) University of Guelph Guelph, Ontario CANADA Publications Jadeski, L.C., Chakraborty, C and Lala, P.K. Role of nitric oxide in tumour progression with special reference to a murine breast cancer model. Canadian Journal of Physiology and Pharmacology 80:125-135, 2002. Jadeski, L., Hum, K. and Lala, P.K. Nitric oxide promotes murine mammary tumour growth and metastasis by stimulating tumour cell migration, invasiveness and angiogenesis. International Journal of Cancer 86:30-39, 2000. Jadeski, and Lala, P.K. Nitric oxide synthase inhibition of NG-Nitro-L-arginine methyl ester inhibits tumour-induced angiogenesis in mammary tumours. American Journal of Pathology 155:1381-1390, 1999. Jadeski, Lorraine and Hoffman-Goetz, Laurie. Exercise and in vivo natural cytotoxicity against tumour cells of varying metastatic capacity. Clinical and Experimental Metastasis 14:138-144, 1996. Jadeski, L., Chakraborty, C. and Lala, P.K. Nitric oxide mediated promotion of tumour cell migration requires signaling through cyclic GMP and MAPK pathways (submitted). Jadeski, L. and Lala, P.K. A novel in vivo assay for tumour-induced angiogenesis in mice to test the therapeutic efficacy of angiogenesis inhibitors (in preparation). Abstracts and Presentations Lala, P.K., Jadeski, L.C. and Chakraborty, C. Signaling mechanisms in nitric-oxide mediated promotion of mammary tumour cell migration. Proceedings of the Reasons for Hope Program Conference, Breast Cancer Research, 2002. Jadeski, L. (2002) The Role of Nitric Oxide in Tumour Progression: A Tribute to the Scientific Contributions of Dr. P.K. Lala. Queen’s University, Kingston, Ontario CANADA, Symposium Address. Lala, P.K., Jadeski, L., Hum, K., Rozic, J. and Chakraborty, C. Cyclooxygenase and nitric oxide synthase inhibitors Jadeski, L., Chakraborty, C. and Lala, P.K. Nitric oxide mediated promotion of mammary tumour cell migration is mediated by signaling through cyclic GMP and MAPK pathways. Proceedings of the American Association for Cancer Research, Volume 42, 2001. Jadeski, L., Hum, K.O., Gleeson, L.M., Chakraborty, C. and Lala, P.K. Nitric oxide mediated promotion of murine mammary tumor progression: role in tumor cell migration. Proceedings of the American Association for Cancer Research, Volume 41, Abstract 1024, 2000. Jadeski, L. and Lala, P.K. The role of nitric oxide in murine mammary tumour-induced angiogenesis. Proceedings of the Reasons for Hope Conference, Breast Cancer Research, Toronto, Ontario, Canada, June 1999 (Platform Address). Lala, P.K., Hum, K. and Jadeski, L. Nitric oxide (NO) synthase expression promotes growth and metastasis of murine breast cancer cells due to invasion an migrating-stimulation by NO. Proceedings of the Reasons for Hope Conference, Breast Cancer Research , Toronto, Ontario, Canada, June 1999. Lala, P.K., Jadeski, L., Hum, K., Rozic, J. and Chakraborty, C. Proceedings AACR-NCI-EORTC International Conference, Abstract 406(83), 1999. Jadeski, L. and Lala, P.K. Role of nitric oxide in murine mammary tumor angiogenesis. Proceedings of the Metastasis Research Society, San Diego, California, USA, Abstract PA5.13, October, 1998. Jadeski, L. and Lala, P.K. Role of nitric oxide in murine mammary tumor angiogenesis. Proceedings of the American Association for Cancer Research, New Orleans, LA, USA, Volume 39, Abstract 2574, March 1998 (Poster Discussion). Lala, P.K., Hum, K., Jadeski, L. and Orucevic, A. Nitric oxide mediated tumor progression: role of NO in tumor cell invasiveness. Proceedings of the “Era of Hope” Conference on Breast Cancer, U.S. Army Medical Research Materiel Command, Washington D.C., Volume III, page 709 - 710, 1997. Hum, K., Jadeski, L., Orucevic, A. and Lala, P.K. Relationship of nitric oxide synthesizing ability to progression of mammary tumors. Proceedings Can. Fed. Soc., 40(227), 1997. Jadeski, L. and Hoffman-Goetz, L. Impact of exercise training on tumor metastasis in mice with the beige mutation genotype. Proceedings of the Federation of American Societies for Experimental Biology Conference, Atlanta, Georgia, USA, Abstract A2099, 1995. Teaching Experience University of Guelph Department of Human Biology and Nutritional Sciences 2002 – 2003 Gross Human Anatomy University of Western Ontario Department of Anatomy and Cell Biology 1997 - 2000 Gross Human Anatomy, Occupational Therapy and Physiotherapy Students 1996 - 1997 Histology, Dental Students University of Waterloo Department of Health Studies and Gerontology 1994 Disease Processes, Undergraduate Students Growth, Development and Aging, Undergraduate Students Environmental Health, Undergraduate Correspondence Students