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EDUCATION
" Ph.D. Molecullar, Cellular and Developmental Biology, Tsinghua
University, China. (1998-2000).
" M.S. Biochemistry and Biophysics, Lanzhou Univeristy, China.
(1993-1996).
" B.S. Zoology, Lanzhou Univeristy, China. (1989-1993).
RESEARCH & ACADEMIC BACKGROUND
Postdoctoral Fellow. Pathology Department, Brigham and Women's Hospital
and Harvard Medical School.(April 2004 to present)
Research focus:IQGAP1's dimerization and it's function
Postdoctoral fellow. Ophythalmology Department, Wilmer Eye Institute,
School of Medicine, Johns Hopkins University, Baltimore, Maryland. (Sept.,
2001 to April, 2004).
Research focus:
" Regulation of PEDF(pigment epithelium derived factor) on the
diabetic retinopathy
" Mechanism of HIV causing eye diseases
" Isolation and characterization of the PEDF receptor
Ph.D. Molecullar, Cellular and Developmental Biology, Tsinghua University,
China. (1998-2001). Research Focus:
" Mechanisms of telomere and telomerase regulation apoptosis induced
by reactive oxygen species.
" Mechanisms of type I collagen anti-apoptosis induced by reactive
oxygen species.
" Mechanisms of thymus involution and the effect of melatonin on
thymocyte apoptosis.
M.S. Biochemistry and Biophysics, Lanzhou Univeristy, China. (1993-1996).
Research focus:
" Role of reactive oxygen species in proliferation, differentiation
and apoptosis of cancer cells.
" Protective mechanisms of natural products from Chinese herbal
medicine on oxidative damage of cells.
SKILLS
" Cell culture; cDNA library construction; Gene clone and vector
construction; Expression cloning; Cell migration; TUNEL; Flow cytometry;
Southern blot; Western blot; PCR; Transfection of heterologous DNA in
mammalian cell lines; Enzymatic isolation of endothelial cell; Digital
imaging microscopy; Affinity chromatography; Immunofluorescence; Immunohistochemical
techniques; ELISA; Organ transplanting; Transmission electron microscope;
Cryo- and paraffin- section.
HONORS AND AWARDS
" Tsinghua University Guanghua Scholarship 1999, 2000
" Lanzhou University Excellent Graduate Student Scholarship 1996
" Lanzhou University Excellent Undergraduate Student Scholarship,
First Prize, 1990, 1991, 1992, 1993.
ADDITIONAL BACKGROUND
" Adjunct faculty member in charge of the operation and maintenance
of CM120 Biotwin Electron Microscopy in the Lab of Transmission Electron
Microscope, Biol Dept., Tsinghua University, China (1998-2001)
" Director of the Fermentation department, Digestation department
and Packing department in Shandong Three Strain Pharmaceutical Co. Ltd.,
China.(1996-1998)
" Teaching Assistant serving as instructor for isotopic tracer
technique course in Lanzhou University, China. (Feb, 1994-July, 1994)
PUBLICATIONS
1. Zheng, R.L.; Kang, J.H.; Chen, F.Y.; Wang, P.F.; Ren, J.G. and Liu,
Q.L. Difference in antioxidation for schisandrins and schisantherin
between Bio- and chemo- systems. Phytotherapy Research 1997; 11:600-602
2. Ren,J.G.; Zheng, R.L.; Shi, Y.M.; Gong, B. and Li, J.F. Apoptosis,
redifferentiation and arresting proliferation simultaneously triggered
by oxidatively stress in human hepatoma cells. Cell Biology International
1998; 22:41-49
3. Ren, J.G.; Li, J.F. and Zheng, R.L Effects of oxidative stress on
the proliferation, differentiation and apoptosis in the human hepatoma
cells. Acta Biologiae Experimentalis Sinica 1998; 31:273-282
4. Ren, J.G.; Zhou, J. and Dai, Y.R. Progress in the studies of telomere
and telomerase. Prog. Biochem. Biophy. 1999; 26: 415-419
5. Dai, Y.R; Ren, J.G.; Tian, Y.M. Overexpression of telomerase inhibits
hydroxyl radical-induced apoptosis in human embryo lung fibroblasts.
Molecullar Cell Biology 2000; 11:1815 Suppl.S
6. Ren, J.G.; Xia, H.L.; Just, T. and Dai, Y.R. Hydroxyl radical-induced
apoptosis in human tumor cells is associated with telomere shortening
but not telomerase inhibiton and caspase activation. FEBS Letters 2001;
488:123-132.
7. Ren, J.G.; Xia, H.L.; Tian, Y.M.; Just, T.; Cai, G.P. and Dai, Y.R.
Expression of telomerase inhibits hydroxyl radical-induced apoptosis
in normal telomerase negative human lung fibroblasts. FEBS Letters 2001;
488:133-138.
8. Ren, J.G.; Xia, H.L. and Dai, Y.R. The changes in telomerase activity
and telomere length in HeLa cells undergoing apoptosis induced by sodium
butyrate. Chineses Science Bulletin 2001; 46:148-153
9. Cheng, J.; Ren, J.G. (Co. first author); Zheng, J.Y.; cai, G.P. and
Dai, Y.R. Expression of Bcl-2 in cells with different telomerase activity.
Chineses Science Bulletin 2001; 46:1980-1984
10. Zhang, L.X.; Hua, Z.C.; Ren, J.G. and Meng, A.M. The nuclear localization
signal of Zebrafish terra is located within the DM domain. FEBS Letters
2001; 503:25-29
11. He, Y.H.; Cheng, J.; Ren J.G.; Wang, G.C. and Cai, G.P. Type I collagen
inhibits hydroxyl radical-induced apoptosis. J. Biochem. 2002; 132(3):373-379
12. Re, J.G.; Chen, J.and Dai, Y.R.Lipid peroxidation-mediated telomere
shortening in hydroxyl radical-induced apoptotsis in HeLa cells. Tsinghua
Sci. Tech. 2002; 6(5):438-445
13. He, Y.H.; Chen J.; Ren, J.G. et al. Hydroxyl radicals-induced apoptosis
is closely related to changes in cellular energy/redox metobolism. Tsinghua
Sci. Tech. 2003; 8(4):407-411
14. Liu, H.; Ren, J.G.; Cooper, W.L.; Hawkins, C.E.; Cowan, M.R. and
Tong, P.Y. Identification of the antivasopermeability effect of pigment
epithelium-derived factor and its active site. Proc Natl Acad Sci U
S A. 2004;101(17):6605-6610
15. Ren, J.G.; Jie, C. and Talbot, C.How PEDF Prevents Angiogenesis:
A Hypothesized Pathway
Medical Hypotheses. 2004, (In pressing)
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